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Olga Genina Selected Research

halofuginone

6/2006Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone.
10/2005Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression.
9/2005Prevention of esophageal strictures in a caustic burn model using halofuginone, an inhibitor of collagen type I synthesis.
2/2004Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes.
9/2002Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats.

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Olga Genina Research Topics

Disease

7Fibrosis (Cirrhosis)
04/2007 - 06/2002
3Liver Cirrhosis (Hepatic Cirrhosis)
04/2007 - 04/2004
3Hepatocellular Carcinoma (Hepatoma)
06/2006 - 09/2002
1Inflammation (Inflammations)
02/2008
1Neoplasms (Cancer)
10/2005
1Wilms Tumor (Wilm's Tumor)
10/2005
1Prostatic Neoplasms (Prostate Cancer)
10/2005
1Pathologic Constriction (Stenosis)
09/2005
1Burns
09/2005
1Acute Liver Failure (Fulminant Hepatic Failure)
04/2004

Drug/Important Bio-Agent (IBA)

5halofuginoneIBA
06/2006 - 09/2002
4Collagen Type I (Type I Collagen)IBA
06/2006 - 09/2002
3Thioacetamide (Thioacetamid)IBA
04/2007 - 02/2004
2Hydroxyproline (4 Hydroxyproline)IBA
04/2004 - 09/2002
2CollagenIBA
02/2004 - 09/2002
1AcidsIBA
02/2008
1Biomarkers (Surrogate Marker)IBA
02/2008
1CurcuminIBA
04/2007
1Tyrosine (L-Tyrosine)FDA Link
06/2006
1Insulin-Like Growth Factor Binding Protein 1IBA
06/2006
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
06/2006
1CausticsIBA
09/2005
1prolinedithiocarbamate (PDTC)IBA
04/2004
1pyrrolidine dithiocarbamic acidIBA
04/2004
1AntioxidantsIBA
04/2004
1NF-kappa B (NF-kB)IBA
04/2004
1Tissue Inhibitor of Metalloproteinase-2IBA
09/2002
1Intravenous Immunoglobulins (IVIG)FDA Link
06/2002

Therapy/Procedure

1Hepatectomy
06/2006
1Intraperitoneal Injections
04/2004
1Therapeutics
06/2002